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Do Breastfed Babies Need HMO Supplements?

Medically Reviewed by May Zhu, RDN | Published September 27, 2024

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Breastfeeding is widely regarded as the gold standard for infant nutrition, offering a wealth of health benefits for both babies and mothers.

A key component that makes breast milk so beneficial is human milk oligosaccharides (HMOs).

These complex carbohydrates play an essential role in shaping the infant gut microbiome, supporting immune health, and promoting overall development.

However, even breastfed babies may benefit from additional HMO supplementation.  In this blog, we'll review the benefits of HMO supplementation for breastfed babies. 

The Composition of HMOs Varies Among Mothers

The HMO composition of breast milk is unique to each mother and influenced by factors such as genetics, diet, and health status.

One significant determinant is the mother's secretor status.

Approximately 80% of women are “secretors,” meaning they produce higher levels of key HMOs, particularly 2’-fucosyllactose (2’-FL).

This HMO is known for its ability to support gut health and immunity (Zivkovic et al., 2011).

Non-secretor mothers, on the other hand, produce lower concentrations of 2’-FL and other critical HMOs. This variability means that even breastfed babies may not always receive the full spectrum of HMOs needed for optimal health.

Supplementing with HMOs like 2’-FL can bridge these gaps, ensuring babies get the gut and immune support they need.

HMOs Change Throughout Lactation

The dynamic nature of breast milk is another reason for HMO supplementation. Breast milk evolves as the infant grows, with HMO concentrations and types varying throughout the stages of lactation:

  • Colostrum (the first milk) is rich in HMOs, giving the infant’s gut and immune system a strong start.
  • Transitional milk maintains high levels of HMOs, though the composition begins to shift.
  • Mature milk andlate lactation milk contain fewer HMOs as breastfeeding continues (German et al., 2008).

These natural changes can leave periods when the infant’s gut receives a less robust supply of HMOs.

Supplementing with HMOs can provide consistent support, particularly as the baby grows and HMO concentrations in milk decrease.

Supporting Gut and Immune Health

One of the primary benefits of HMOs is their ability to nurture the infant gut microbiome and strengthen immune defenses. HMOs act as prebiotics, feeding beneficial bacteria likeBifidobacterium infantis and Bifidobacterium lactis.

These bacteria are crucial for establishing a healthy gut microbiome, which plays a significant role in digestion, immunity, and overall health (Goehring et al., 2016).

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HMOs also help protect against harmful pathogens by preventing bacteria and viruses from attaching to the gut lining. This protection is vital for reducing the risk of infections and supporting a developing immune system.

Conclusion

While breastfeeding offers significant health advantages, the natural variation in HMO composition among mothers and across lactation stages can lead to gaps in gut and immune support. HMO supplementation provides a consistent and reliable source of these vital nutrients, helping to boost immune function, promote gut health, and support a baby’s overall development.

Summary

Breast milk’s HMO composition varies among mothers and changes throughout lactation, which may leave gaps in immune and gut support for babies. Supplementing with HMOs, such as those found in Beginbaby Prebiotic + Probiotics ensures consistent intake, helping breastfed babies thrive with better gut and immune health support. 

View Citation

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  2. Gabrielli, O., Zampini, L., Galeazzi, T., Peila, C., Giuliani, F., Salari, P., et al. (2011). Preterm milk human milk oligosaccharides during the first month of lactation. Pediatrics, 128(6), e1520-1531.
  3. Seppo, A. E., Kukkonen, A. K., Kuitunen, M., Savilahti, E., & Haahtela, T. (2015). Breast milk oligosaccharides and development of cow's milk allergy in infants. Journal of Allergy and Clinical Immunology, 135(4), 1046-1051.
  4. Urashima, T., Kitaoka, M., & Teruya, K. (2018). Chapter 2: Milk Oligosaccharides. In Comprehensive Glycoscience(Vol. 4, pp. 63-88). Elsevier.
  5. Goehring, K. C., Kennedy, A. D., Prieto, P. A., & Buck, R. H. (2014). Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants. PLoS One, 9(7), e101692.